Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
Identifieur interne : 003848 ( Main/Exploration ); précédent : 003847; suivant : 003849Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
Auteurs : Yasuhiro Yoshimatsu [Japon] ; Yulia G. Lee [Corée du Sud] ; Yuichi Akatsu [Japon] ; Luna Taguchi [Japon] ; Hiroshi I. Suzuki [Japon] ; Sara I. Cunha [Suède] ; Kazuichi Maruyama [Japon] ; Yuka Suzuki [Japon] ; Tomoko Yamazaki [Japon] ; Akihiro Katsura [Japon] ; S. Paul Oh ; Teresa A. Zimmers ; Se-Jin Lee ; Kristian Pietras [Suède] ; Gou Young Koh [Corée du Sud] ; Kohei Miyazono [Japon] ; Tetsuro Watabe [Japon]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2013.
Abstract
Because lymphatic vessels (LVs) play critical roles not only in physiological processes such as maintenance of fluid homeostasis but also in pathological conditions including cancer metastasis, identification of factors that control LV formation is crucial. Signals mediated by activin receptor-like kinase 1 (ALK-1), a receptor for bone morphogenetic protein 9 (BMP-9), have been implicated in the formation of blood vessels because of its linkage to a human vascular disease. However, their roles in LV formation largely remain to be elucidated. Here, we show that BMP-9/ALK-1 signals inhibit LV formation in physiological and pathological conditions. Furthermore, we elucidated its molecular mechanisms in detail, using both in vivo and in vitro systems. These findings will help develop therapeutic strategies for LV-related diseases such as lymphedema and cancer.
Url:
DOI: 10.1073/pnas.1310479110
PubMed: 24133138
PubMed Central: 3839734
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003170
- to stream Pmc, to step Curation: 003169
- to stream Pmc, to step Checkpoint: 002476
- to stream Ncbi, to step Merge: 005E37
- to stream Ncbi, to step Curation: 005E37
- to stream Ncbi, to step Checkpoint: 005E37
- to stream Main, to step Merge: 003856
- to stream Main, to step Curation: 003848
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression</title><author><name sortKey="Yoshimatsu, Yasuhiro" sort="Yoshimatsu, Yasuhiro" uniqKey="Yoshimatsu Y" first="Yasuhiro" last="Yoshimatsu">Yasuhiro Yoshimatsu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Yulia G" sort="Lee, Yulia G" uniqKey="Lee Y" first="Yulia G." last="Lee">Yulia G. Lee</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Vascular Biology and Stem Cell,<institution>Korea Advanced Institute of Science and Technology</institution>, Daejeon 305-701,<country>South Korea</country>;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akatsu, Yuichi" sort="Akatsu, Yuichi" uniqKey="Akatsu Y" first="Yuichi" last="Akatsu">Yuichi Akatsu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Hiroshi I" sort="Suzuki, Hiroshi I" uniqKey="Suzuki H" first="Hiroshi I." last="Suzuki">Hiroshi I. Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cunha, Sara I" sort="Cunha, Sara I" uniqKey="Cunha S" first="Sara I." last="Cunha">Sara I. Cunha</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medical Biochemistry and Biophysics, Division of Vascular Biology,<institution>Karolinska Institutet</institution>, SE-171 77 Stockholm,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maruyama, Kazuichi" sort="Maruyama, Kazuichi" uniqKey="Maruyama K" first="Kazuichi" last="Maruyama">Kazuichi Maruyama</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Ophthalmology,<institution>Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8574,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Yuka" sort="Suzuki, Yuka" uniqKey="Suzuki Y" first="Yuka" last="Suzuki">Yuka Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamazaki, Tomoko" sort="Yamazaki, Tomoko" uniqKey="Yamazaki T" first="Tomoko" last="Yamazaki">Tomoko Yamazaki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Katsura, Akihiro" sort="Katsura, Akihiro" uniqKey="Katsura A" first="Akihiro" last="Katsura">Akihiro Katsura</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oh, S Paul" sort="Oh, S Paul" uniqKey="Oh S" first="S. Paul" last="Oh">S. Paul Oh</name><affiliation><nlm:aff id="aff5">Department of Physiology and Functional Genomics, College of Medicine,<institution>University of Florida</institution>, Gainesville,<addr-line>FL</addr-line> 32610;</nlm:aff></affiliation></author><author><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name><affiliation><nlm:aff id="aff6">Department of Cancer Biology and Surgery, Kimmel Cancer Center,<institution>Thomas Jefferson University</institution>, Philadelphia,<addr-line>PA 19107</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name><affiliation><nlm:aff id="aff7">Department of Molecular Biology and Genetics,<institution>Johns Hopkins University School of Medicine</institution>, Baltimore,<addr-line>MD</addr-line> 21205;</nlm:aff></affiliation></author><author><name sortKey="Pietras, Kristian" sort="Pietras, Kristian" uniqKey="Pietras K" first="Kristian" last="Pietras">Kristian Pietras</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medical Biochemistry and Biophysics, Division of Vascular Biology,<institution>Karolinska Institutet</institution>, SE-171 77 Stockholm,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff8">Department of Laboratory Medicine Lund,<institution>Lund University</institution>, Medicon Village, SE-223 81 Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Medicon Village, SE-223 81 Lund</wicri:regionArea><wicri:noRegion>SE-223 81 Lund</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Vascular Biology and Stem Cell,<institution>Korea Advanced Institute of Science and Technology</institution>, Daejeon 305-701,<country>South Korea</country>;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Watabe, Tetsuro" sort="Watabe, Tetsuro" uniqKey="Watabe T" first="Tetsuro" last="Watabe">Tetsuro Watabe</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Precursory Research for Embryonic Science and Technology (PRESTO),<country>Japan</country><institution>Science Technology Agency</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24133138</idno><idno type="pmc">3839734</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839734</idno><idno type="RBID">PMC:3839734</idno><idno type="doi">10.1073/pnas.1310479110</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003170</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003170</idno><idno type="wicri:Area/Pmc/Curation">003169</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003169</idno><idno type="wicri:Area/Pmc/Checkpoint">002476</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002476</idno><idno type="wicri:Area/Ncbi/Merge">005E37</idno><idno type="wicri:Area/Ncbi/Curation">005E37</idno><idno type="wicri:Area/Ncbi/Checkpoint">005E37</idno><idno type="wicri:doubleKey">0027-8424:2013:Yoshimatsu Y:bone:morphogenetic:protein</idno><idno type="wicri:Area/Main/Merge">003856</idno><idno type="wicri:Area/Main/Curation">003848</idno><idno type="wicri:Area/Main/Exploration">003848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression</title><author><name sortKey="Yoshimatsu, Yasuhiro" sort="Yoshimatsu, Yasuhiro" uniqKey="Yoshimatsu Y" first="Yasuhiro" last="Yoshimatsu">Yasuhiro Yoshimatsu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Yulia G" sort="Lee, Yulia G" uniqKey="Lee Y" first="Yulia G." last="Lee">Yulia G. Lee</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Vascular Biology and Stem Cell,<institution>Korea Advanced Institute of Science and Technology</institution>, Daejeon 305-701,<country>South Korea</country>;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Akatsu, Yuichi" sort="Akatsu, Yuichi" uniqKey="Akatsu Y" first="Yuichi" last="Akatsu">Yuichi Akatsu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Hiroshi I" sort="Suzuki, Hiroshi I" uniqKey="Suzuki H" first="Hiroshi I." last="Suzuki">Hiroshi I. Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cunha, Sara I" sort="Cunha, Sara I" uniqKey="Cunha S" first="Sara I." last="Cunha">Sara I. Cunha</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medical Biochemistry and Biophysics, Division of Vascular Biology,<institution>Karolinska Institutet</institution>, SE-171 77 Stockholm,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maruyama, Kazuichi" sort="Maruyama, Kazuichi" uniqKey="Maruyama K" first="Kazuichi" last="Maruyama">Kazuichi Maruyama</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Ophthalmology,<institution>Tohoku University Graduate School of Medicine</institution>, Sendai, Miyagi 980-8574,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Yuka" sort="Suzuki, Yuka" uniqKey="Suzuki Y" first="Yuka" last="Suzuki">Yuka Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamazaki, Tomoko" sort="Yamazaki, Tomoko" uniqKey="Yamazaki T" first="Tomoko" last="Yamazaki">Tomoko Yamazaki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Katsura, Akihiro" sort="Katsura, Akihiro" uniqKey="Katsura A" first="Akihiro" last="Katsura">Akihiro Katsura</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oh, S Paul" sort="Oh, S Paul" uniqKey="Oh S" first="S. Paul" last="Oh">S. Paul Oh</name><affiliation><nlm:aff id="aff5">Department of Physiology and Functional Genomics, College of Medicine,<institution>University of Florida</institution>, Gainesville,<addr-line>FL</addr-line> 32610;</nlm:aff></affiliation></author><author><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name><affiliation><nlm:aff id="aff6">Department of Cancer Biology and Surgery, Kimmel Cancer Center,<institution>Thomas Jefferson University</institution>, Philadelphia,<addr-line>PA 19107</addr-line>;</nlm:aff></affiliation></author><author><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name><affiliation><nlm:aff id="aff7">Department of Molecular Biology and Genetics,<institution>Johns Hopkins University School of Medicine</institution>, Baltimore,<addr-line>MD</addr-line> 21205;</nlm:aff></affiliation></author><author><name sortKey="Pietras, Kristian" sort="Pietras, Kristian" uniqKey="Pietras K" first="Kristian" last="Pietras">Kristian Pietras</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medical Biochemistry and Biophysics, Division of Vascular Biology,<institution>Karolinska Institutet</institution>, SE-171 77 Stockholm,<country>Sweden</country>;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff8">Department of Laboratory Medicine Lund,<institution>Lund University</institution>, Medicon Village, SE-223 81 Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Medicon Village, SE-223 81 Lund</wicri:regionArea><wicri:noRegion>SE-223 81 Lund</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Vascular Biology and Stem Cell,<institution>Korea Advanced Institute of Science and Technology</institution>, Daejeon 305-701,<country>South Korea</country>;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Watabe, Tetsuro" sort="Watabe, Tetsuro" uniqKey="Watabe T" first="Tetsuro" last="Watabe">Tetsuro Watabe</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Pathology, Graduate School of Medicine,<institution>The University of Tokyo</institution>, Bunkyo-ku, Tokyo 113-0033,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Precursory Research for Embryonic Science and Technology (PRESTO),<country>Japan</country><institution>Science Technology Agency</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Because lymphatic vessels (LVs) play critical roles not only in physiological processes such as maintenance of fluid homeostasis but also in pathological conditions including cancer metastasis, identification of factors that control LV formation is crucial. Signals mediated by activin receptor-like kinase 1 (ALK-1), a receptor for bone morphogenetic protein 9 (BMP-9), have been implicated in the formation of blood vessels because of its linkage to a human vascular disease. However, their roles in LV formation largely remain to be elucidated. Here, we show that BMP-9/ALK-1 signals inhibit LV formation in physiological and pathological conditions. Furthermore, we elucidated its molecular mechanisms in detail, using both in vivo and in vitro systems. These findings will help develop therapeutic strategies for LV-related diseases such as lymphedema and cancer.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Japon</li><li>Suède</li></country></list><tree><noCountry><name sortKey="Lee, Se Jin" sort="Lee, Se Jin" uniqKey="Lee S" first="Se-Jin" last="Lee">Se-Jin Lee</name><name sortKey="Oh, S Paul" sort="Oh, S Paul" uniqKey="Oh S" first="S. Paul" last="Oh">S. Paul Oh</name><name sortKey="Zimmers, Teresa A" sort="Zimmers, Teresa A" uniqKey="Zimmers T" first="Teresa A." last="Zimmers">Teresa A. Zimmers</name></noCountry><country name="Japon"><noRegion><name sortKey="Yoshimatsu, Yasuhiro" sort="Yoshimatsu, Yasuhiro" uniqKey="Yoshimatsu Y" first="Yasuhiro" last="Yoshimatsu">Yasuhiro Yoshimatsu</name></noRegion><name sortKey="Akatsu, Yuichi" sort="Akatsu, Yuichi" uniqKey="Akatsu Y" first="Yuichi" last="Akatsu">Yuichi Akatsu</name><name sortKey="Katsura, Akihiro" sort="Katsura, Akihiro" uniqKey="Katsura A" first="Akihiro" last="Katsura">Akihiro Katsura</name><name sortKey="Maruyama, Kazuichi" sort="Maruyama, Kazuichi" uniqKey="Maruyama K" first="Kazuichi" last="Maruyama">Kazuichi Maruyama</name><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><name sortKey="Suzuki, Hiroshi I" sort="Suzuki, Hiroshi I" uniqKey="Suzuki H" first="Hiroshi I." last="Suzuki">Hiroshi I. Suzuki</name><name sortKey="Suzuki, Yuka" sort="Suzuki, Yuka" uniqKey="Suzuki Y" first="Yuka" last="Suzuki">Yuka Suzuki</name><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><name sortKey="Watabe, Tetsuro" sort="Watabe, Tetsuro" uniqKey="Watabe T" first="Tetsuro" last="Watabe">Tetsuro Watabe</name><name sortKey="Watabe, Tetsuro" sort="Watabe, Tetsuro" uniqKey="Watabe T" first="Tetsuro" last="Watabe">Tetsuro Watabe</name><name sortKey="Yamazaki, Tomoko" sort="Yamazaki, Tomoko" uniqKey="Yamazaki T" first="Tomoko" last="Yamazaki">Tomoko Yamazaki</name></country><country name="Corée du Sud"><noRegion><name sortKey="Lee, Yulia G" sort="Lee, Yulia G" uniqKey="Lee Y" first="Yulia G." last="Lee">Yulia G. Lee</name></noRegion><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name></country><country name="Suède"><noRegion><name sortKey="Cunha, Sara I" sort="Cunha, Sara I" uniqKey="Cunha S" first="Sara I." last="Cunha">Sara I. Cunha</name></noRegion><name sortKey="Pietras, Kristian" sort="Pietras, Kristian" uniqKey="Pietras K" first="Kristian" last="Pietras">Kristian Pietras</name><name sortKey="Pietras, Kristian" sort="Pietras, Kristian" uniqKey="Pietras K" first="Kristian" last="Pietras">Kristian Pietras</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003848 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003848 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3839734
|texte= Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24133138" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |